Transmembrane Helices in Genome Sequences (THGS v2), an interactive web based database, has been developed to search the transmembrane helices in the user-defined genome available in the Genome Database (GDB). The software has the provision to further explore for the occurrence of Identical/Similar sequence motifs and repeats in the other sequence databases (SWISS-PROT, PIR and PDB). In addition, it can be used to visualize the three-dimensional structure of the corresponding queried motifs or repeats, if it is available in the Protein Data Bank. The Sequence databases used in the present work are being updated immediately as and when the appropriate GDB site is updated. Hence the results produced by THGS v2 are up-to-date at any given time.